My work spans genetics, clinical epidemiology, imaging, and AI across multiple ophthalmic disease areas.
Genome-wide association studies (GWAS) and multi-omics analyses for AMD, myopia, glaucoma, and pachychoroid diseases. Identification of novel susceptibility loci and disease mechanisms.
View related publications →Pathogenesis, genetic risk stratification, and treatment outcomes of neovascular AMD, pachychoroid neovasculopathy, and geographic atrophy in Asian populations.
View related publications →Epidemiology and genetics of myopia and high myopia; axial length progression; myopic macular neovascularization; interventions to prevent myopia onset and progression.
View related publications →Genetic risk factors for primary open-angle glaucoma; surgical outcomes of minimally invasive glaucoma surgery (MIGS); OCT/OCTA-based structural assessment. Currently developing an adjustable microfluidic glaucoma implant.
View related publications →Central serous chorioretinopathy, polypoidal choroidal vasculopathy, and the pachychoroid spectrum — genetics, imaging phenotyping, and treatment.
View related publications →Deep learning for ophthalmic image analysis (OCT, fundus); AI-based diagnosis; evaluation of large language models (GPT-4) in ophthalmology.
View related publications →Nationwide population-based cohort studies using Japanese claims databases and registry data (Nagahama Study, JOIR, Japan-RD Registry, NDB).
View related publications →Structural and vascular retinal imaging using optical coherence tomography and OCT angiography; novel imaging biomarkers for disease monitoring.
View related publications →Broad clinical and translational research across inherited and acquired retinal disorders, including disease registries and outcomes research.
View related publications →Collaborations
Large-scale resources contributing to my epidemiological and clinical research.
A community-based prospective cohort of ~9,850 healthy adults (aged 30–74) from Nagahama City, Shiga Prefecture, established in 2008. Provides comprehensive ocular biometry, imaging, and multi-omics data for population-level investigation of myopia, AMD, glaucoma, and retinal aging in Japanese individuals.
View related publications (30) →A national real-world ophthalmology database established by the Japanese Ophthalmological Society (2017), housing hundreds of thousands of fundus photographs, OCT images, and visual field records from 22+ institutions. Serves as key infrastructure for AI model development and epidemiological studies of ocular and systemic disease.
View related publications (4) →A nationwide multicenter registry collecting clinical data on rare retinal diseases in Japan. Enables characterization of prevalence, natural history, and treatment outcomes across Japanese institutions.
View related publications (1) →Japan's national administrative claims database covering ~98% of all healthcare encounters nationwide since 2009. Contains de-identified insurance claims and health checkup data from all Japanese insurers, enabling large-scale population-based analyses of surgical trends, drug utilization, and disease incidence in ophthalmology.
View related publications (13) →